PDGF, PDRN & Exosomes: Which Skin Rejuvenation Upgrade Is Right for You?

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Dr. Chet Mays

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7/7/2026

If you've visited The Spa at MPS or spent time researching advanced skincare treatments, you've probably come across a few abbreviations that sound more like a science class than a facial treatment: PDGF, PDRN, and exosomes.

So...what do they actually mean?

While all three are designed to support healthier, more radiant skin, they each work a little differently and offer unique benefits. At The Spa at MPS, we offer these regenerative treatments as facial enhancements because they help take great treatments - like microneedling - to the next level.

Let's decode the acronyms and explore what makes each one unique.

First, What Is Regenerative Aesthetics?

Regenerative aesthetics focuses on helping your skin repair, renew, and rebuild itself naturally.

Rather than simply treating the surface, these advanced therapies work by supporting your body's healing process and encouraging healthier skin over time. They're commonly paired with treatments like microneedling to enhance collagen production, improve recovery, and maximize results.

Think of them as giving your skin a little extra support while it's doing what it already knows how to do - heal.

PDGF: The Collagen Booster

PDGF (Platelet-Derived Growth Factor) is the one of our most popular regenerative upgrades.

Growth factors are naturally involved in your body's healing process, and PDGF helps signal your skin to repair itself and produce new collagen. When paired with treatments like microneedling, it helps support recovery while enhancing overall skin rejuvenation.

Patients often choose PDGF to help improve:

  • Fine lines and wrinkles
  • Skin texture
  • Collagen production
  • Overall skin rejuvenation

PDGF isn't just for facial rejuvenation, either. At The Spa at MPS, we also use PDGF scalp injections to support hair restoration by creating an environment that encourages healthier hair growth.

PDRN: The Viral "Salmon Sperm Facial"

You've probably seen PDRN making headlines on social media - often referred to as the "salmon sperm facial."

Despite the nickname, PDRN (Polydeoxyribonucleotide) is all about supporting skin repair and improving overall skin quality.

Derived from purified salmon DNA, PDRN has become a favorite for patients looking to improve hydration, elasticity, and radiance while supporting the skin's natural healing process.

At The Spa at MPS, PDRN is available as a regenerative facial upgrade and is also incorporated into our Salmon Sperm Facial, giving patients another way to experience this innovative treatment.

Patients love PDRN for:

  • Hydration
  • Brighter, healthier-looking skin
  • Improved skin elasticity
  • Supporting skin repair

Exosomes: The Advanced Skin Communicator

Exosomes are tiny messenger particles that help cells communicate with one another during the healing process.

In aesthetics, they're used to support skin regeneration, calm inflammation, and encourage healthier, stronger-looking skin following treatments like microneedling.

Because they help optimize your skin's natural repair response, exosomes have become one of the most exciting advancements in regenerative skincare.

Patients often choose exosomes to:

  • Support post-treatment healing
  • Improve skin quality
  • Enhance collagen production
  • Promote a smoother, healthier complexion

Which Upgrade Is Right for You?

The best news? You don't have to figure it out on your own.

Every patient's skin is different, and the right regenerative treatment depends on your concerns, your goals, and the treatment you're having.

Whether you're focused on collagen production, hydration, improving skin quality, or enhancing recovery after microneedling, our providers will help you determine which option is the best fit.

You Don't Have to Speak "Aesthetic"

It's easy to feel overwhelmed by all the new ingredients and technologies in the skincare world.

The good news is - you don't have to memorize the acronyms.

That's what we're here for.

During your consultation, our licensed aestheticians will evaluate your skin, explain the differences between each regenerative treatment, and recommend the option that will provide the greatest benefit for your unique skin goals.

The Bottom Line

PDGF, PDRN, and exosomes all have one thing in common: they're designed to help your skin look healthier, stronger, and more radiant.

While each works a little differently, they're all exciting tools that allow us to customize your treatment and evaluate your results.

Whether you're interested in enhancing your next microneedling appointment, exploring our PDRN "Salmon Sperm Facial," or learning more about PDGF for hair restoration, we're here to help you choose the treatment that's right for you.

Schedule your complimentary skincare consultation today , and let our team create a personalized plan designed around your skin - not just the latest trend.

I absolutely love Dr. Mays and his team. From the moment you walk in, the staff is kind, welcoming, and always responsive. Dr. Mays makes you feel completely comfortable and confident in your choices. He listens carefully to what you want and brings your vision to life without ever pressuring you into anything. His work is absolutely phenomenal and the results speak for themselves.Trina does my Botox and she is professional, precise, and makes the experience so easy and relaxed.The entire team goes above and beyond to make you feel cared for and supported. I couldn’t recommend them more highly to anyone looking for a plastic surgeon and aesthetic team that truly delivers amazing results.

J.F. Google

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E.P. Google

I visited Mays Plastic Surgery Nov. 21st and had a great experience with both Meredith and Trina.Meredith did a Diamond Glow facial on me which gave me an incredible glow that I received multiple compliments on even days after my appointment. It was such a relaxing experience and Meredith made me feel so comfortable and she also prepped me to get filler and I felt literally zero discomfort when getting filler. The facial was so relaxing I didn't even want to get up out of the cozy little bed.Trina did my filler for both my undereyes and jawline. She gave great recommendations for what type of filler to use and placement. She made me feel very comfortable and was incredibly gentle during the procedure - I couldn't even tell where she'd injected me afterwards. The hollowness in my undereyes has been significantly reduced and my jawline looks so much more defined and pretty, even my neck under my chin looks better. I'm so pleased with following Trina's recommendations! My friends and coworkers have all asked about it and want to get it done themselves now!Thank you Meredith and Trina, you all were awesome!! 100% recommend them!

M.S. Google

Trina is very good, very detailed, and she listens! So far, as a transferred client, I'm pleased with the services rendered. The facility is absolutely beautiful, immaculate, very classy and elegant! The men's bathroom is off the chain! 🙌🏾🙌🏾🙌🏾🙌🏾🙌🏾🙌🏾

J.M. Google

The diamond glow facial was so relaxing, and Meredith was so sweet!

S.B. Google

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